Histone H3 Rabbit Polyclonal Antibody (HRP)
Product Information
Downloads & Supports
Target
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H3C1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/5000-1/10000
Immunogen
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A synthetic peptide corresponding to the carboxy terminus of the human histone H3 protein.
Molecular Weight
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Calculated MW: 15 kDa; Observed MW: 15 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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8350
Uniprot ID
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P68431
Background
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Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.MiscellaneousThis histone is only present in mammals and is enriched in acetylation of Lys-15 and dimethylation of Lys-10 (H3K9me2).
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H3 histone; HIST1H3A; Histone cluster 1; H3a