Anti-ZAP70 (4B2) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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ZAP70
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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4B2-C1-H3
Isotype
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IgG2b
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IP: 1/20
Immunogen
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Purified recombinant human ZAP-70 protein fragments expressed in E.coli.
Molecular Weight
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Calculated MW: 70 kDa; Observed MW: 70 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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7535
Uniprot ID
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P43403
Background
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The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement. Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck.
Research Area
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Immunology
Synonyms
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ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase