Anti-XRCC4 (7C10) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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XRCC4
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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7C10-5H8-4F8
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20
Immunogen
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Synthetic Peptide of XRCC4
Molecular Weight
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Calculated MW: 38 kDa; Observed MW: 38-45 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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7518
Uniprot ID
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Q13426
Background
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Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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X ray repair cross complementing protein 4; DNA repair protein XRCC4; DNA double strand break repair