Anti-XPD Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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ERCC2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R02-7Y5
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Immunogen
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A synthesized peptide derived from human XPD
Molecular Weight
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Calculated MW: 87 kDa; Observed MW: 75 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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2068
Uniprot ID
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P18074
Background
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ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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BTF2 p80; COFS2; CXPD; EM9; ERCC2; MAG; TFIIH p80; TTD; XPD; XPDC