Anti-WRN Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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WRN
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R03-8U2
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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A synthesized peptide derived from human WRN
Molecular Weight
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Calculated MW: 162 kDa; Observed MW: 200 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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7486
Uniprot ID
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Q14191
Background
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Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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Exonuclease WRN; RecQ3; RECQL2; RECQL3; Werner syndrome helicase; WRN