Anti-Vinculin Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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VCL
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R02-6L-2
Isotype
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IgG
Reactivity
Application
Application Details
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IHC: 1/100-1/200
Immunogen
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A synthesized peptide derived from human Vinculin
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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7414
Uniprot ID
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P18206
Background
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Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development. Three structural vinculin domains include an amino-terminal head, a short, flexible proline-rich region and a carboxy-terminal tail. In the inactive state, the head and tail domains of vinculin interact to form a closed confirmation. The open and active form of vinculin translocates to focal adhesions where it is thought to be involved in anchoring F-actin to the membrane and regulation of cell migration.
Research Area
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Signal Transduction
Synonyms
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VCL; Vinculin; Metavinculin