Anti-UCHL3 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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UCHL3
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R07-1K4
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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A synthesized peptide derived from human UCHL3
Molecular Weight
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Calculated MW: 26 kDa; Observed MW: 26 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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7347
Uniprot ID
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P15374
Background
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Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling.
Research Area
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Cell Biology
Synonyms
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UCH-L3; Ubiquitin thiolesterase L3; Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCHL3