Anti-TUSC3 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
TUSC3
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/200
Immunogen
-
Synthetic peptide corresponding to Human TUSC3.
Molecular Weight
-
Calculated MW: 40kDa
Formulation
-
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Form
-
Liquid
Gene ID
-
7991
Uniprot ID
-
Q13454
Background
-
Made up of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome.
Research Area
-
-
Synonyms
-
Tumor suppressor candidate 3; Magnesium uptake/transporter TUSC3; Protein N33; TUSC3; N33