Anti-TriMethyl-Histone H3 (Lys4) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
H3-4
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ChIP: 1:20 - 1:100
Immunogen
-
A synthetic methylated peptide corresponding to residues surrounding K4 of human histone H3
Molecular Weight
-
Calculated MW: 16 kDa; Observed MW: 16 kDa
Formulation
-
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
8290
Uniprot ID
-
Q16695
Background
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
H3K4me3; H3 histone; HIST1H3A; Histone cluster 1; H3a