Anti-TRIM21 (5B9) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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TRIM21
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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5B9-B9-H8
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Purified recombinant human TRIM21 protein fragments expressed in E.coli.
Molecular Weight
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Calculated MW: 54 kDa; Observed MW: 50 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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6737
Uniprot ID
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P19474
Background
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This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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SSA; RO52; SSA1; RNF81; Ro/SSA