Anti-Transcription Factor AP 2 beta Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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TFAP2B
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Synthetic peptide of human TFAP2B
Molecular Weight
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Calculated MW: 50 kDa; Observed MW: 50 kDa
Formulation
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pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
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Liquid
Gene ID
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7021
Uniprot ID
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Q92481
Background
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This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
Research Area
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Synonyms
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transcription factor AP-2 beta (activating enhancer binding protein 2 beta); AP-2B; AP2-B