Anti-TRAF2 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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TRAF2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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4D8-G8-T3
Isotype
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IgG2a/lamda
Reactivity
Application
Application Details
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WB：1/500-1/1000，ICC/IF：1/50
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 53 kDa; Observed MW:53 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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7186
Uniprot ID
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Q12933
Background
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Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
Research Area
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Tumor biology
Synonyms
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TRAP3