Anti-Torsin 1A Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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TOR1A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R08-3H1
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 FC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human Torsin A
Molecular Weight
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Calculated MW: 38 kDa; Observed MW: 35 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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1861
Uniprot ID
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O14656
Background
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The neurological condition Dystonia is associated with sustained muscle contractions and abnormal posturing. TorsinA, torsinB, torp2A and torp3A belong to the family of ATPases associated with cellular activites (AAA+) and mutations in torsinA cause early onset dystonia. TorsinA has been shown to suppress intracellular protein aggregation in C. elegans and possesses chaperon activity. Interestingly, torsinA is highly expressed in dopaminergic neurons and associates with alpha-synuclein in Lewy bodies, which pathologically characterize Parkinson's Disease.
Research Area
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Neuroscience
Synonyms
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TOR1A; DQ2; DYT1; TorsinA