Anti-Toll-Like Receptor 1 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
TLR1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
-
Fusion protein of human TLR1
Molecular Weight
-
Calculated MW: 90 kDa; Observed MW: 90 kDa
Formulation
-
pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
-
Liquid
Gene ID
-
7096
Uniprot ID
-
Q15399
Background
-
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.
Research Area
-
Immunology
Synonyms
-
Toll-Like Receptor 1; TIL; CD281; rsc786; TIL. LPRS5