Anti-TIM3 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
HAVCR2
Host
Storage
-
Store at -20°C to -80°C for 12 months in lyophilized form.
Clonality
Clone Number
-
R07-1A-8
Isotype
-
IgG
Reactivity
Application
Application Details
-
FC: 1/50-1/100 ELISA: 1/10000
Immunogen
-
Recombinant human TIM3 protein
Molecular Weight
-
-
Formulation
-
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Form
-
Lyophilized
Gene ID
-
84868
Uniprot ID
-
Q8TDQ0
Background
-
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
Research Area
-
Immunology
Synonyms
-
HAVcr-2; TIMD-3; TIM-3; CD366