Anti-Thymidylate Synthase Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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TYMS
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R09-8C-8
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 36 kDa; Observed MW:36 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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7298
Uniprot ID
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P04818
Background
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Thymidylate synthase is a homodimer composed of two 30 kDa subunits, which catalyze the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), an essential step in the formation of thymine nucleotides. Thymidylate synthase is an intracellular enzyme that provides the sole de novo source of thymidylate, making it a required enzyme in DNA biosynthesis with activity highest in proliferating cells. Being the exclusive source of dTMP, investigators have concluded that TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU). 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head, and neck.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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TYMS, TSase