Anti-Synphilin-1 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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SNCAIP
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clonality
Clone Number
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Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/200
Immunogen
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Synthetic peptide corresponding to Human Synphilin-1.
Molecular Weight
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Calculated MW: 100kDa
Formulation
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1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Form
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Liquid
Gene ID
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9627
Uniprot ID
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Q9Y6H5
Background
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Synphilin-1 (α-synuclein interacting protein, SNCAIP) is a 919 amino acid protein that associates with α synuclein and promotes the formation of cytosolic inclusions in neuronal cells. The synuclein family members, including α-synuclein and β-synuclein, are predominantly expressed in the brain, where they influence synaptic regulation and neuronal plasticity. Synphilin-1 contains modular protein domains, such as ankyrin-like repeats and a coiled-coil domain.While both α-synuclein and synphilin-1 are coexpressed in Lewy bodies of patients with Parkinson’s disease, only mutations in the gene for α-synuclein have been determined to confer pathogenicity.
Research Area
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Synonyms
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Synphilin-1; Sph1; Alpha-synuclein-interacting protein; SNCAIP