Anti-SV40 T Antigen Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R08-7D4
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Immunogen
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A synthetic peptide of SV40 T-antigen
Molecular Weight
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Calculated MW: 82 kDa; Observed MW: 90 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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29031019
Uniprot ID
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P03070
Background
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Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA. Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA.
Research Area
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Infectious Diseases
Synonyms
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Large T antigen; LT; LT-AG