Anti-Superoxide Dismutase 1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
SOD1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R07-1G6
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
-
A synthetic peptide of human Superoxide Dismutase 1
Molecular Weight
-
Calculated MW: 16 kDa; Observed MW: 16 kDa
Formulation
-
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
-
Liquid
Gene ID
-
6647
Uniprot ID
-
P00441
Background
-
SOD1, Cu/Zn superoxide dismutase, is a major antioxidant enzyme that catalyzes the conversion of superoxide anion to hydrogen peroxide and molecular oxygen. The mechanism by which mutant SOD1 induces the neurodegeneration observed in ALS is still unclear. Mutant SOD1 proteins become misfolded and consequently oligomerize into high molecular weight species that aggregate and end up in proteinaceous inclusions.
Research Area
-
Signal Transduction
Synonyms
-
SOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1