Anti-SOX2 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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SOX2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R74-1A-2
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/100-1/200 IF: 1/50-1/200
Immunogen
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A synthesized peptide derived from human SOX2
Molecular Weight
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Calculated MW: 34 kDa;Observed MW:34kDa
Formulation
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Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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6657
Uniprot ID
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P48431
Background
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Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Research Area
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Neuroscience
Synonyms
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SOX2; ANOP3; MCOPS3; MGC2413; lcc; SRY related HMG box 2;