Anti-SOX2 (2A10) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
SOX2
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
2A10-F11-F12
Isotype
-
IgG1
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/100 ICC: 1/150 FC: 1/100
Immunogen
-
Purified recombinant mouse Sox2 protein
Molecular Weight
-
Calculated MW: 34 kDa
Formulation
-
Liquid in PBS with 0.09% (W/V) sodium azide
Form
-
Liquid
Gene ID
-
6657
Uniprot ID
-
P48431
Background
-
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Research Area
-
Neuroscience
Synonyms
-
Transcription factor SOX-2; ANOP3; MCOPS3