Anti-SOCS7 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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SOCS7
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R27-4V-7
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/100-1/200
Immunogen
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A synthesized peptide derived from human SOCS7
Molecular Weight
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Calculated MW:63kDa;Observed MW:63kDa
Formulation
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Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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30837
Uniprot ID
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O14512
Background
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Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA.
Research Area
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Signal Transduction
Synonyms
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Ash and phospholipase C gamma-binding protein; NAP4; Nck; Nck Ash and phospholipase C binding protein; Nck associated protein 4; NCKAP4; SH2 domain containing SOCS box protein; SOCS4; SOCS6; Socs7; Suppressor of cytokine signaling 7;