Anti-SIGMAR1 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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SIGMAR1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
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Fusion protein of human SIGMAR1
Molecular Weight
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Calculated MW: 25 kDa; Observed MW: 25 kDa
Formulation
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pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
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Liquid
Gene ID
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10280
Uniprot ID
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Q99720
Background
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This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
Research Area
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Synonyms
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sigma non-opioid intracellular receptor 1; SRBP; ALS16; OPRS1; SR-BP; SIG-1R; SR-BP1; sigma1R