Anti-Septin 1 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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SEPTIN1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clonality
Clone Number
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Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/200
Immunogen
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Synthetic peptide corresponding to Human Septin 1.
Molecular Weight
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Calculated MW: 42kDa
Formulation
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1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Form
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Liquid
Gene ID
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1731
Uniprot ID
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Q8WYJ6
Background
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The septins are a family of GTPase enzymes, some of which are required for cytokinesis and others of which are associated with exocytosis. Members of the septin family can form heteropolymer complexes and also play a role in the organization of new growth in organisms. The transcriptional regulation of all septins is complex, resulting in alternatively spliced variants. At least three septins (Septin 1, 2 and 4) are associated with a Tau-based paired helical filament core and may contribute to the formation of neurofibrillary tangle as integral constituents of paired helical filaments. Septin 3 (G-Septin), a GTP-binding protein, is highly expressed in brain and is regulated by protein kinase G in neurons. The human SEPT4 (H5/PNUTL2/CDCrREL-2) gene encodes ARTS (for apoptosis-related protein in the TGFβ signaling pathway), which is expressed in many cells and acts to enhance cell death induced by TGFβ or, to a lesser extent, by other apoptotic agents.
Research Area
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Synonyms
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Septin-1; LARP; Peanut-like protein 3; Serologically defined breast cancer antigen NY-BR-24; SEPT1; DIFF6; PNUTL3