Anti-SAE1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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SAE1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R05-3Q1
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/50 FC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human SAE1
Molecular Weight
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Calculated MW: 38 kDa; Observed MW: 38 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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10055
Uniprot ID
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Q9UBE0
Background
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The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Research Area
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Cell Biology
Synonyms
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SAE1; AOS1; SUA1; UBLE1A; SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A