Anti-RRS1 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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RRS1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/200
Immunogen
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Synthetic peptide corresponding to Human RRS1.
Molecular Weight
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Calculated MW: 42kDa
Formulation
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1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Form
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Liquid
Gene ID
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23212
Uniprot ID
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Q15050
Background
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RRS1, also known as KIAA0112, ribosome biogenesis regulatory protein homolog, regulator of ribosome synthesis 1, ribosome biogenesis regulatory protein RRS1 homolog or RRR, is a 365 amino acid protein belonging to the RRS1 family. RRS1 shows nucleolar localization and is involved in both ribosome biogenesis and chromosome congression. Recent studies indicate that in the absence of RRS1, cells experience mitotic delay due to abnormal spindle organization and chromosome alignment. The gene encoding RRS1 maps to human chromosome 8q13.1. Consisting of nearly 146 million base pairs, chromosome 8 encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.
Research Area
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Synonyms
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Homolog of yeast ribosome biogenesis regulator; Homolog of yeast ribosome biogenesis regulatory protein RRS1; KIAA0112; OTTHUMP00000227420; Ribosome biogenesis regulatory protein homolog; Ribosome biogenesis regulatory protein RRS1 homolog; RRR; rrs1;