Anti-ROS1 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
ROS1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
4D9-6A7-10G9
Isotype
-
IgG2a
Reactivity
Application
Application Details
-
IHC: 1/100-1/500
Immunogen
-
Synthesized peptide derived from human ROS1
Molecular Weight
-
-
Formulation
-
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
6098
Uniprot ID
-
P08922
Background
-
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Research Area
-
Signal Transduction
Synonyms
-
ROS; MCF3; c-ros-1