Anti-RNF114 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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RNF114
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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IHC: 1/50-1/100
Immunogen
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Fusion protein of human RNF114
Molecular Weight
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-
Formulation
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pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
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Liquid
Gene ID
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55905
Uniprot ID
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Q9Y508
Background
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E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885).In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287).
Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885).
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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E3 ubiquitin-protein ligase RNF114;RING finger protein 114;Zinc finger protein 228;Zinc finger protein 313;ZNF228, ZNF313