Anti-Ras(A146V Mutant) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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H-Ras, K-Ras, N-Ras
Host
Storage
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Store at -20°C. Avoid repeated freezing and thawing
Clonality
Clone Number
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1X6-S2-T2
Isotype
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IgG
Reactivity
Application
Application Details
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ELISA: 1/1000-1/5000 WB: 1/500-1/1000 IHC-P: 1/50-1/100
Immunogen
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A synthetic peptide from the internal region of Ras which includes the mutation of A146V, human origin.
Formulation
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PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Form
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Liquid
Uniprot ID
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Background
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The A146V mutation of KRas results in an amino acid substitution at position 146, from an alanine to a threonine. KRAS encodes a protein that is a member of the small GTPase superfamily. Ras A146V mutation results in decreased GTPase activity and constitutive signaling. It can be found in many tumors, such as lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.
Research Area
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Cell Biology
Synonyms
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H-Ras, K-Ras, N-Ras