Anti-Rad9 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
RAD9A
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
3A3-A7-F8
Isotype
-
IgG2b
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IP: 1/20
Immunogen
-
Purified recombinant human RAD9A protein fragments expressed in E.coli
Molecular Weight
-
Calculated MW: 43 kDa; Observed MW: 55 kDa
Formulation
-
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
5883
Uniprot ID
-
Q99638
Background
-
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
RAD9; hRAD9