Anti-Pyruvate Dehydrogenase E1 alpha Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
PDHA1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
3H2-F8-B5
Isotype
-
IgG1
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
-
Purified recombinant human Pyruvate Dehydrogenase protein fragments expressed in E.coli.
Molecular Weight
-
Calculated MW: 43 kDa; Observed MW: 43 kDa
Formulation
-
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
5160
Uniprot ID
-
P08559
Background
-
The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Catalyzes the removal of CO2 from pyruvate. Mutations in the α subunits of pyruvate dehydrogenase (E1) lead to congenital defects that are usually associated with lactic acidosis, neurodegeneration and early death.
Research Area
-
Signal Transduction
Synonyms
-
mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; PHE1A; Pyruvate Dehydrogenase (lipoamide) alpha 1; Pyruvate dehydrogenase complex; E1 alpha polypeptide 1; Pyruvate Dehydrogenase E1 alpha; Pyruvate dehydrogenase E1 component subunit alpha; Pyruvate dehydrogenase E1 component subunit alpha; somatic form; mitochondrial; somatic form.