Anti-PTEN(R130G Mutant) Mouse mAb
Product Information
Downloads & Supports
Target
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PTEN, 10q23del, BZS, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, MMAC1, PTEN1, TEP1
Host
Storage
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Store at -20°C. Avoid repeated freezing and thawing
Clonality
Clone Number
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9A7-P6-W1
Isotype
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IgG
Reactivity
Application
Application Details
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ELISA: 1/1000-1/5000 WB: 1/500-1/1000
Immunogen
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A synthetic peptide from the internal region of PTEN which includes the mutation of R130G, human origin.
Formulation
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PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Form
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Liquid
Uniprot ID
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Background
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Phosphatase and tensin homolog (PTEN) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency.I t is one of the most commonly lost tumor suppressors in human cancer. During tumor development, mutations and deletions of PTEN occur that inactivate its enzymatic activity leading to increased cell proliferation and reduced cell death. Frequent genetic inactivation of PTEN occurs in glioblastoma, endometrial cancer,and prostate cancer; and reduced expression is found in many other tumor types such as lung and breast cancer.
Research Area
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Cell Biology
Synonyms
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PTEN, 10q23del, BZS, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, MMAC1, PTEN1, TEP1