Anti-PSMA Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
FOLH1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R04-6I6
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/50
Immunogen
-
A synthesized peptide derived from human PSMA
Molecular Weight
-
Calculated MW: 84 kDa; Observed MW: 110 kDa
Formulation
-
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
-
Liquid
Gene ID
-
2346
Uniprot ID
-
Q04609
Background
-
PSMA has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Research Area
-
Signal Transduction
Synonyms
-
FGCP; FOLH 1; GCP 2; GCPII; mGCP; NAALADase I; PSM; PSMA