Anti-Presenilin 1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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PSEN1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R01-3J6
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 FC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human Presenilin 1
Molecular Weight
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Calculated MW: 53 kDa; Observed MW: 35 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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5663
Uniprot ID
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P49768
Background
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Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity.
Research Area
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Neuroscience
Synonyms
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PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182