Anti-PPP4C (2F11) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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PPP4C
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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2F11-D10-G4
Isotype
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IgG2a
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Immunogen
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Purified recombinant human Protein Phosphatase 4C protein fragments expressed in E.coli.
Molecular Weight
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Calculated MW: 35 kDa; Observed MW: 35 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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5531
Uniprot ID
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P60510
Background
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In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family.
Research Area
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Signal Transduction
Synonyms
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PP4; PPX; PP4C; PPH3; PPP4