Anti-POLD1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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POLD1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R05-3H1
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Immunogen
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A synthetic peptide of human DNA Polymerase delta, catalytic subunit
Molecular Weight
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Calculated MW: 124 kDa; Observed MW: 124 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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5424
Uniprot ID
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P28340
Background
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Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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CDC2; CRCS10; MDPL; POLD; POLD1