Anti-PLCG1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
PLCG1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R81-6X-8
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/50
Immunogen
-
A synthesized peptide derived from human PLC gamma 1
Molecular Weight
-
Calculated MW: 149 kDa;Observed MW:149kDa
Formulation
-
Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
-
Liquid
Gene ID
-
5335
Uniprot ID
-
P19174
Background
-
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras.
Research Area
-
Cardiovascular
Synonyms
-
PLC-148; PLC-II; PLC-gamma1; PLC1; PLCG-1; Phospholipase C-gamma-1;