Anti-PIM2 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
PIM2
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R04-5D8
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IP: 1/20
Immunogen
-
A synthetic peptide of human PIM2
Molecular Weight
-
Calculated MW: 34 kDa; Observed MW: 40,38,34 kDa
Formulation
-
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
-
Liquid
Gene ID
-
11040
Uniprot ID
-
Q9P1W9
Background
-
Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappaB kinase/NF-kappaB cascade; this process requires phosphorylation of MAP3K8/COT. Prevents apoptosis induced by growth factor withdrawal via inhibition of caspase-3 activation, and via phosphorylation of pro-apoptotic proteins.
Research Area
-
Signal Transduction
Synonyms
-
PIM2; Serine/threonine-protein kinase pim-2; Pim-2h