Anti-PI3 Kinase p110 alpha Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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PIK3CA
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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3C1-6F9-6C4
Isotype
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IgG1
Reactivity
Application
Application Details
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IHC: 1/100-1/500
Immunogen
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Synthesized peptide derived from human PIK3CA H1047R
Molecular Weight
-
-
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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5290
Uniprot ID
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P42336
Background
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Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.
Research Area
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Signal Transduction
Synonyms
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phosphatidylinositol-4; 5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphoinositide-3-kinase catalytic alpha polypeptide; PI3-kinase p110 alpha; PI3K; PI3K p110-alpha; PK3CA; PtdIns-3-kinase p110