Anti-Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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TAOK1/TAOK2/TAOK3
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R04-3I5
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
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A synthetic phosphopeptide corresponding to residues surrounding Ser181 of human TAOK1
Molecular Weight
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Calculated MW: 116 kDa; Observed MW: 105,116,138 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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51347/57551/9344
Uniprot ID
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Q7L7X3/Q9H2K8/Q9UL54
Background
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Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6.
Research Area
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Synonyms
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DPK; JIK; hKFC-A; MAP3K18