Anti-Phospho-SNAI1 (Ser246) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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SNAI1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 ICC: 1/100-1/200
Immunogen
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Synthetic peptide of human SNAI1
Molecular Weight
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Calculated MW: 29 kDa; Observed MW: 29 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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6615
Uniprot ID
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O95863
Background
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Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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SNAH; Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna