Anti-Phospho-Smad3 (Ser425) (7H6) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
SMAD3
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
7H6-4E5-4H2
Isotype
-
IgG1
Reactivity
Application
Application Details
-
IHC: 1/50-1/100
Immunogen
-
Synthetic peptide conjugated to KLH.
Molecular Weight
-
-
Formulation
-
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
4088
Uniprot ID
-
P84022
Background
-
Smad3 transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse required for establishemnt of the mucosal immune response and proper development of skeleton.
Research Area
-
Signal Transduction
Synonyms
-
SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3