Anti-Phospho-RSK1 p90 (Thr359/Ser363) Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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RPS6KA1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R33-5H-9
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/100-1/200 IF: 1/50-1/200 IP: 1/50
Immunogen
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A synthesized peptide derived from human Phospho-RSK1 p90 (T359+S363)
Molecular Weight
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Calculated MW: 83 kDa;Observed MW:90kDa
Formulation
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Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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6195
Uniprot ID
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Q15418
Background
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Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine / threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB.
Research Area
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Signal Transduction
Synonyms
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RSK; HU-1; MAPKAPK1A; RPS6KA1;p90 RSK1; RPS6K1 ; RSK 1 p90; S6K alpha 1; 90 kDa ribosomal protein S6 kinase 1 Ribosomal S6 kinase 1;