Anti-Phospho-MLKL (Ser358) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
MLKL
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/100
Immunogen
-
A synthesized peptide derived from human Phospho-MLKL (S358)
Molecular Weight
-
Calculated MW: 54 kDa; Observed MW: 54 kDa
Formulation
-
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
-
Liquid
Gene ID
-
197259
Uniprot ID
-
Q8NB16
Background
-
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Research Area
-
Signal Transduction
Synonyms
-
MLKL