Anti-Phospho-LRRK2 (Ser935) Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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LRRK2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R94-3M-6
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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A synthesized peptide derived from human Phospho-LRRK2 (S935)
Molecular Weight
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Calculated MW:286kDa;Observed MW:286kDa
Formulation
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Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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120892
Uniprot ID
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Q5S007
Background
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The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
Research Area
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Neuroscience
Synonyms
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AURA17;Dardarin; LRRK2; LRRK 2; PARK8; RIPK7; ROCO2;