Anti-Phospho-IKK alpha/beta (Ser176/180) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
CHUK
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000
Immunogen
-
A synthetic phosphorylated peptide around S176 of human IKK-alpha
Molecular Weight
-
Calculated MW: 85 kDa; Observed MW: 85 kDa
Formulation
-
Liquid in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Form
-
Liquid
Gene ID
-
1147
Uniprot ID
-
O15111
Background
-
Plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation.
Research Area
-
Signal Transduction
Synonyms
-
CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B