Anti-Phospho-IKB alpha (Ser36) Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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NFKBIA
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R87-2A-5
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 FC: 1/50
Immunogen
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A synthesized peptide derived from human Phospho-IKB alpha (S36)
Molecular Weight
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Calculated MW: 36 kDa;Observed MW:39kDa
Formulation
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Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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4792
Uniprot ID
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P25963
Background
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Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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I kappa B alpha; IkappaBalpha; IkB-alpha; IKBA; IKBalpha; MAD3; NF kappa B inhibitor alpha; NFKBI; NFKBIA;