Anti-Phospho-Histone H2A.X (Ser139) Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
H2AX
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R09-4A7
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IP: 1/20
Immunogen
-
A synthetic phosphopeptide corresponding to residues surrounding Ser139 of human gamma H2A.X
Molecular Weight
-
Calculated MW: 15 kDa; Observed MW: 15 kDa
Formulation
-
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
-
Liquid
Gene ID
-
3014
Uniprot ID
-
P16104
Background
-
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
H2A.X; H2AFX; H2a/x; HIST5-2AX; Histone H2A.X; gamma H2A.X