Anti-Phospho-Histone H2A.X (Ser139) (7G9) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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H2AX
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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7G9-H4
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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Synthetic phosphopeptide corresponding to residues surrounding Ser139 of human H2A.X.
Molecular Weight
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Calculated MW: 15 kDa; Observed MW: 15 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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3014
Uniprot ID
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P16104
Background
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Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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H2A.X; H2AFX; H2a/x; HIST5-2AX; Histone H2A.X; gamma H2A.X