Anti-Phospho-Glycogen synthase 1(Ser645) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
GYS1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000
Immunogen
-
Synthetic phosphopeptide derived from human Glycogen synthase 1 around the phosphorylation site of Serine 645.
Molecular Weight
-
-
Formulation
-
1 mg/ml in PBS with 0.05% sodium azide,pH 7.3.
Form
-
Liquid
Gene ID
-
2997
Uniprot ID
-
P13807
Background
-
Glycogen is a polysaccharide of glucose and serves as an energy storage in mammalian muscle and liver. Glycogen synthase catalyzes the rate-limiting step of glycogen biosynthesis and has two major isoforms in mammals -- muscle isoform (GYS1) and liver isoform (GYS2) respectively. Glycogen synthase kinase-3α (GSK-3α) and glycogen synthase kinase-3β (GSK-3β) phosphorylate glycogen synthase at multiple sites in its C-terminus (Ser641, Ser645, Ser649 and Ser653) inhibiting its activity. Hypoxia alters glycogen metabolism including temporal changes of GYS1 expression and phosphorylation in cancer cells, suggesting the role of metabolic reprogramming of glycogen metabolism in cancer growth.
Research Area
-
-
Synonyms
-
Glycogen [starch] synthase, muscle; GYS1; GYS